Reaction of 3-Methylamino-1,2-diols with Dihalomethanes. Synthesis of Chiral 4-Substituted 3-Methyltetrahydro-1,3-oxazin-5-ols

6533b7d7fe1ef96bd1268ee8

RESEARCH PRODUCT

Reaction of 3-Methylamino-1,2-diols with Dihalomethanes. Synthesis of Chiral 4-Substituted 3-Methyltetrahydro-1,3-oxazin-5-ols

Maria Luisa Testa José Sepúlveda-arques Elena Zaballos-garcía Chakib Hajji Juan Server-carrió Roberto De La Salud-bea

subject

chemistry.chemical_classification chemistry.chemical_compound chemistry Organic Chemistry Drug Discovery Organic chemistry Regioselectivity Oxazines Biochemistry Dichloromethane

description

Abstract Enantiomerically pure 4,5-disubstituted 3-methyltetrahydro-1,3-oxazines have been obtained by reaction of 3-methylamino-1,2-diols with dichloromethane by regioselective differentiation of hydroxyl groups.

year	journal	country	edition	language
2000-10-01	Tetrahedron

https://doi.org/10.1016/s0040-4020(00)00744-4

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