6533b7d7fe1ef96bd126907e
RESEARCH PRODUCT
THE ROLE OF EXTRACELLULAR VESICLES IN MODULATING THE HOST IMMUNE RESPONSE DURING PARASITIC INFECTIONS
Alicia GalianoAntonio MarcillaDolores BernalSergio MontanerLorena Martin-jaularHernando A. Del PortilloHernando A. Del PortilloMarãa Trelissubject
lcsh:Immunologic diseases. AllergyImmunologyReview ArticleimmunomodulationExtracellular vesiclesprotozoaImmune systemProtozoan infectionHelminthsImmunodulationparasitic diseasesmedicineImmunology and AllergyParasite hostingHelminthshelminthProtozoan InfectionsbiologyHost (biology)biology.organism_classificationmedicine.diseaseImmunologyparasiteProtozoaextracellular vesicleslcsh:RC581-607description
Parasites are the cause of major diseases affecting billions of people. As the inflictions caused by these parasites affect mainly developing countries, they are considered as neglected diseases. These parasitic infections are often chronic and lead to significant immunomodulation of the host immune response by the parasite, which could benefit both the parasite and the host and are the result of millions of years of co-evolution. The description of parasite extracellular vesicles (EVs) in protozoa and helminths suggests that they may play an important role in host–parasite communication. In this review, recent studies on parasitic (protozoa and helminths) EVs are presented and their potential use as novel therapeutical approaches is discussed.
| year | journal | country | edition | language |
|---|---|---|---|---|
| 2014-09-08 | Frontiers in Immunology |