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RESEARCH PRODUCT

Developmental and Early Life Origins of Cardiometabolic Risk Factors

Empar LurbeEmpar LurbeJulie R. Ingelfinger

subject

AdultEpigenomicsMaleProteomicsGerontologyAgingAdolescentBirth weightGestational Age030204 cardiovascular system & hematologyCardiovascular SystemEpigenesis Genetic03 medical and health sciences0302 clinical medicineMetabolic DiseasesAdverse Childhood ExperiencesPregnancyRisk FactorsInternal MedicineBirth WeightHumansMetabolomics030212 general & internal medicinePrecision MedicinePostnatal growthChildImprinting (organizational theory)High birth weightCardiometabolic riskMicrobiotaInfant NewbornInfantInfant Low Birth WeightMiddle AgedEarly lifeAdult lifeCardiovascular DiseasesChild PreschoolPrenatal Exposure Delayed EffectsFemalePsychologyRelevant informationInfant PrematureForecasting

description

The intent of this review is to critically consider the data that support the concept of programming and its implications. Birth weight and growth trajectories during childhood are associated with cardiometabolic disease in adult life. Both extremes, low and high birth weight coupled with postnatal growth increase the early presence of cardiometabolic risk factors and vascular imprinting, crucial elements of this framework. Data coming from epigenetics, proteomics, metabolomics, and microbiota added relevant information and contribute to better understanding of mechanisms as well as development of biomarkers helping to move forward to take actions. Research has reached a stage in which sufficiently robust data calls for new initiatives focused on early life. Prevention starting early in life is likely to have a very large impact on reducing disease incidence and its associated effects at the personal, economic, and social levels.

yearjournalcountryeditionlanguage
2021-02-01Hypertension
https://doi.org/10.1161/hypertensionaha.120.14592