6533b7d7fe1ef96bd1269135
RESEARCH PRODUCT
Clinical relevance of polymorphic markers of arterial thrombosis.
Elvira GrandoneG. Di MinnoMaurizio Margaglionesubject
Genetic MarkersPathologymedicine.medical_specialtyPolymorphism GeneticGenetic inheritanceArterial diseaseVascular diseasebusiness.industryChromosome MappingThrombosisHematologyPeptidyl-Dipeptidase Amedicine.diseaseBioinformaticsThrombosisIschemiaRisk FactorsGenetic markermedicineHumansClinical significanceProspective cohort studybusinessVascular Medicinedescription
Case-control and cross-sectional studies show that some common molecular variations (polymorphisms) of genes coding for proteins involved in atherosclerosis and thrombosis are often present in subjects who have experienced cerebrovascular or cardiovascular events. The clinical impact of the majority of polymorphic markers is disputed by prospective reports. In contrast, their pathophysiological implications and their role in monitoring parameters that are difficult to be checked by alternative means, are documented by the large majority of the reports. From the evidence available, there may be suggestion for further impact of polymorphic markers in vascular medicine. To substantiate this, new prospective studies that include individuals from different geographical areas and that take into account the statistical power, the informativeness of the markers, the coexistance of established risk factors and the genetic background of the populations analyzed, are urgently needed.
| year | journal | country | edition | language |
|---|---|---|---|---|
| 1997-07-01 |