6533b7d7fe1ef96bd1269176

RESEARCH PRODUCT

Cost-efficacy of oral triptans in the treatment of acute migraine

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SummaryThe objective of this study was to compare the efficiency of oral triptans currently used in the treatment of acute migraine in Spain. Using a decision analytic model, a cost-efficacy analysis was performed from the payer's perspective. Efficacy was assessed in terms of sustained pain-free patients, with data extracted from a recent meta-analysis of clinical trials. Chest-related and central nervous system-related adverse events were also considered. For the economic analysis, the cost of drug treatment and the management of adverse events were determined.A group of three triptans (naratriptan 2.5 mg, sumatriptan 50 mg and almotriptan 12.5 mg) was found to dominate all other triptans in the sense that the other triptans were more expensive but did not show higher efficacy. Naratriptan 2.5 mg offered the lowest cost of the three, while almotriptan 12.5 mg showed the highest level of efficacy. The incremental cost-efficacy ratio for sumatriptan 50 mg versus naratriptan 2.5 mg was €23.09 per sustained...