Role of humanin, a mitochondrial-derived peptide, in cardiovascular disorders

6533b7d8fe1ef96bd126989e

RESEARCH PRODUCT

Role of humanin, a mitochondrial-derived peptide, in cardiovascular disorders

Alexandre Meloux Luc Rochette Catherine Vergely Yves Cottin Marianne Zeller

subject

Cell Peptide 030204 cardiovascular system & hematology Mitochondrion medicine.disease_cause Cardiovascular System 03 medical and health sciences 0302 clinical medicine [SDV.MHEP.CSC]Life Sciences [q-bio]/Human health and pathology/Cardiology and cardiovascular system Animals Humans Medicine 030212 general & internal medicine Endothelial dysfunction ComputingMilieux_MISCELLANEOUS Humanin chemistry.chemical_classification business.industry Intracellular Signaling Peptides and Proteins General Medicine medicine.disease Mitochondria Up-Regulation Cell biology Oxidative Stress Open reading frame medicine.anatomical_structure chemistry Cardiovascular Diseases Inflammation Mediators Cardiology and Cardiovascular Medicine business Function (biology)Oxidative stress Signal Transduction

description

The mitochondria produce specific peptides-mitochondrial-derived peptides-that mediate the transcriptional stress response by their translocation into the nucleus and interaction with deoxyribonucleic acid. Mitochondrial-derived peptides are regulators of metabolism. This class of peptides comprises humanin, mitochondrial open reading frame of the 12S ribosomal ribonucleic acid type c (MOTS-c) and small humanin-like peptides (SHLPs). Humanin inhibits mitochondrial complex 1 activity and limits the level of oxidative stress in the cell. Data show that mitochondrial-derived peptides have a role in improving metabolic diseases, such as type 2 diabetes. Perhaps humanin can be used as a marker for mitochondrial function in cardiovascular disease or as a pharmacological strategy in patients with endothelial dysfunction. The goal of this review is to discuss the newly emerging functions of humanin, and its biological role in cardiovascular disorders.

year	journal	country	edition	language
2020-08-01	Archives of Cardiovascular Diseases

https://doi.org/10.1016/j.acvd.2020.03.020

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