6533b7d8fe1ef96bd1269924

RESEARCH PRODUCT

Human CD4+CD25+ regulatory T cells and infectious tolerance.

Helmut JonuleitMichael StassenEdgar Schmitt

subject

CD4-Positive T-LymphocytesTransplantationbusiness.industryPeripheral toleranceReceptors Interleukin-2T lymphocyteNatural killer T cellT-Lymphocytes RegulatoryMolecular biologyImmune toleranceInterleukin 21ImmunologyImmune ToleranceHumansCytotoxic T cellMedicineIL-2 receptorbusinessInterleukin 3

description

Control of autoaggressive T cells by regulatory T cells (Treg) is essential to ensuring peripheral tolerance. Several subsets of CD(4+) T cells with suppressive properties have been described, including induced T helper (Th) type 3 and T regulatory (Tr) type 1 cells and naturally occurring CD(4+)CD(25+) Treg. CD(4+)CD(25+) Treg suppress the response of conventional T cells in a cell contact-dependent manner, whereas Th3 and Tr1 cells produce immunosuppressive cytokines. Two subsets of human CD(4+)CD(25+) Treg, characterized by expression of the integrins alpha4beta7 or alpha4beta1, are able to convey suppressive capacity to conventional CD(4+) T cells, thereby generating Th suppressor cells (Th(sup)). One outstanding feature is the generation of Th(sup) with distinct properties. alpha4beta7 Treg induce Tr1-like interleukin (IL)-10-producing Th(sup), whereas alpha4beta1 Treg induce Th3-like Th(sup), which produce transforming growth factor (TGF)-beta. Thus, our findings reconcile contradictory results clearly demonstrating that suppression is contact dependent in vitro but mediated by soluble factors (IL-10 and TGF-beta) in vivo.

yearjournalcountryeditionlanguage
2004-01-17Transplantation
https://doi.org/10.1097/00007890-200401151-00009