6533b7d8fe1ef96bd1269a7c

RESEARCH PRODUCT

Mutual influences between Nitric Oxide and Paraoxonase 1

subject

description

Este artículo se ha publicado de forma definitiva en: https://www.mdpi.com/2076-3921/8/12/619 Este artículo pertenece al número especial "Paraoxonase in Oxidation and Inflammation". One of the best consolidated paradigms in vascular pharmacology is that an uncontrolled excess of oxidizing chemical species causes tissue damage and loss of function in the endothelial and subendothelial layers. The fact that high-density lipoproteins play an important role in preventing such an imbalance is integrated into that concept, for which the expression and activity of paraoxonases is certainly crucial. The term paraoxonase (aryldialkyl phosphatase, EC 3.1.8.1) encompasses at least three distinct isoforms, with a wide variation in substrate a nity, cell and fluid localization, and biased expression of polymorphism. The purpose of this review is to determine the interactions that paraoxonase 1 has with nitric oxide synthase, its reaction product, nitric oxide (nitrogen monoxide, NO), and its derived reactive species generated in an oxidative medium, with a special focus on its pathological implications.