6533b7d8fe1ef96bd1269abd

RESEARCH PRODUCT

Effcts of Dextran Sulphate (Dxs) on Lymphocyte Localization in Complement-Deficient Mice: Evidence that the Fifth Component of Complement is not Implicated in the Dxs Activity

Di Fiore PA. BellaviaSalerno ARomano Gc

subject

RatónLymphocyteImmunologyCellCell CommunicationBiologyToxicologyMicechemistry.chemical_compoundCell MovementmedicineAnimalsLymphocytesComplement ActivationLymph nodePharmacologyComplement component 5Dextran SulfateComplement C5DextransBiological activityMolecular biologymedicine.anatomical_structureDextranMechanism of actionchemistryImmunologyFemaleLymph Nodesmedicine.symptom

description

AbstractThe effects of subcutaneously or intraperitoneally administered dextran sulphate (DXS) (5nmg/kg) on the subseguent 1 h localization of intravenously injected radiolabelled lymph node cells was investigated in complement deficient mice which lack C5.DXS proved to be equally as potent in depressing cell localizzation in deficient as compared to normal mice. These findings. indicate that the terminal complement components are not, essential for DXS activity.

yearjournalcountryeditionlanguage
1984-01-01Journal of Immunopharmacology
https://doi.org/10.3109/08923978409026462