6533b7d8fe1ef96bd1269ad3

RESEARCH PRODUCT

Crystalloid lysozyme inclusions in Paneth cells of vitamin A-deficient rats.

Burkard Schulz-dobrickHelmut E. GabbertHans Konrad BiesalskiHans-p. DienesHarald WeiserK. H. BässlerE. StofftMartin J. Koch

subject

VitaminMalemedicine.medical_specialtyHistologyBiologydigestive systemPathology and Forensic Medicinechemistry.chemical_compoundImmunityInternal medicinemedicineAnimalsSecretionInclusion BodiesVitamin A DeficiencyRetinolRats Inbred StrainsCell BiologyMolecular medicineImmunohistochemistryRatsmedicine.anatomical_structureEndocrinologyJejunumchemistryBiochemistryPaneth cellUltrastructureLysozymeLysosomes

description

The effect of vitamin A-deficiency on jejunal Paneth cells in rats was investigated. Crystalloid particles were observed in secretion granules of Paneth cells from 6 out of 8 rats with vitamin A-deficiency. The particles were similar to those found in Paneth cells under other experimental conditions. Using an immuno-electron-microscopic technique we demonstrated a clear lysozyme immunoreactivity of these particles. In 2 vitamin A-deficient rats tubular structures have been detected in addition to the crystalloid particles. Crystalloid particles or tubular structures were not detectable in a control group of 8 vitamin A-supplemented rats. The morphological alterations of Paneth cells may be correlated to an impaired local immunity of the intestine during vitamin A-deficiency.

10.1007/bf00297244https://pubmed.ncbi.nlm.nih.gov/2164886