6533b7d8fe1ef96bd1269af5
RESEARCH PRODUCT
Supported Ionic Liquid Asymmetric Catalysis. A New Method for Chiral Catalysts Recycling. The Case of Proline-Catalyzed Aldol Reaction.
Renato NotoPaolo Lo MeoMichelangelo GruttadauriaSerena RielaFrancesca D'annasubject
inorganic chemicalsChemistrySilica gelorganic chemicalsOrganic ChemistryInorganic chemistryEnantioselective synthesisGeneral MedicineBiochemistryCombinatorial chemistryCatalysischemistry.chemical_compoundAldol reactionCovalent bondPhase (matter)Drug DiscoveryMonolayerIonic liquiddescription
A new method for chiral catalysts recycling, based on the supported ionic liquid asymmetric catalysis concept, has been developed. This concept involves the treatment of a monolayer of covalently attached ionic liquid on the surface of silica gel with additional ionic liquid. These layers serve as the reaction phase in which the homogeneous chiral catalyst is dissolved. As first application of this concept the L-proline-catalyzed aldol reaction has been carried out. Good yields and ee values, comparable with those obtained under homogeneous conditions have been obtained. Moreover, this material shows high regenerability.
| year | journal | country | edition | language |
|---|---|---|---|---|
| 2004-11-09 | ChemInform |