6533b7d8fe1ef96bd1269ba2
RESEARCH PRODUCT
Interactions between the yeast mitochondrial and nuclear genomes: isogenic suppressive and hypersuppressive petites differ in their resistance to the alkaloid lycorine
Domenica Rita MassardoKlaus Werner WolfL. Del GiudiceF. Mannasubject
GeneticsMitochondrial DNAMutationbiologyAlkaloidSaccharomyces cerevisiaeMutantDrug Resistance MicrobialSaccharomyces cerevisiaeGeneral Medicinebiology.organism_classificationLycorinemedicine.disease_causeDNA MitochondrialMolecular biologyGenomeYeastPhenanthridineschemistry.chemical_compoundchemistryAmaryllidaceae AlkaloidsGeneticsmedicineDNA Fungaldescription
In a previous paper we have shown that the alkaloid lycorine inhibits growth of rho+, mit- and rho-, strains of Saccharomyces cerevisiae, whereas strains devoid of mitochondrial DNA (rho degrees) are resistant to more than 200 micrograms/ml of the alkaloid. In this report we show that hypersuppressive petites are almost as resistant as rho degrees mutants, whereas isogenic rho- petites, which have retained longer segments of the genome, are sensitive to the drug.
| year | journal | country | edition | language |
|---|---|---|---|---|
| 1990-05-01 | Current Genetics |