6533b7d8fe1ef96bd126a2e4
RESEARCH PRODUCT
Immunotherapy targeting colon cancer stem cells
Vitanna SaladinoGiorgio StassiMarisa SpinaFrancesco DieliFlora IovinoSerena MeravigliaMatilde TodaroValentina Orlandosubject
cancer stem cellsAdoptive cell transferT-LymphocytesT cellImmunologyBiologyCell therapyNK-92T-Lymphocyte SubsetsCancer stem cellmedicinegamma delta T cellsHumansImmunology and AllergyNK cellSettore MED/04 - Patologia Generalecolon cancer stem cellschemoresistanceReceptors Antigen T-Cell gamma-deltaSuicide geneKiller Cells Naturalmedicine.anatomical_structureOncologyColonic NeoplasmsImmunologyCancer cellNeoplastic Stem CellsImmunotherapygamma delta T cells cancer stem cells chemoresistance immunotherapy NK cellStem celldescription
In the last 10 years, cancer stem cells have interested the scientific community because this small tumorigenic population is also associated with tumor progression in human patients and specific targeting of cancer stem cells could be a strategy to eradicate cancers currently resistant to conventional therapy. Clinical studies have recently demonstrated that adding immune therapy to chemotherapy has survival benefits in comparison with chemotherapy alone that can sensitize tumors to immune cell-mediated killing (e.g., increasing sensitivity of tumor cells to subsequent cytotoxicity by T cells via upregulation of death receptors DR5 and Fas). However, loss of MHC molecules is often observed in cancer cells, rendering tumor cells resistant to CD8 T-cell-mediated cytotoxicity. For this reason, we review the role of other T-cell subsets, such as γδ T and NK cells that are able to efficiently recognize and kill tumor cells and that could be used in passive or active immunotherapy in cancer stem cell eradication.
| year | journal | country | edition | language |
|---|---|---|---|---|
| 2010-12-23 | Immunotherapy |