6533b7d8fe1ef96bd126a377

RESEARCH PRODUCT

Increased seroprevalence of parvovirus B 19 IgG in complex regional pain syndrome is not associated with antiendothelial autoimmunity

Gunter HempelmannMichael E. BräuFrank BirkleinO. GrossFranz BlaesKatharina MadlenerMarlene TschernatschManfred Kaps

subject

AdultMalevirusesEnzyme-Linked Immunosorbent AssayAntibodies Viralmedicine.disease_causeAutoimmune DiseasesAutoimmunityParvoviridae InfectionsPathogenesisSeroepidemiologic StudiesParvovirus B19 HumanmedicineHumansSeroprevalenceEndotheliumAgedAutoantibodiesbiologybusiness.industryParvovirusAutoantibodyvirus diseasesMiddle Agedbiology.organism_classificationmedicine.diseaseAnesthesiology and Pain MedicineComplex regional pain syndromeImmunoglobulin GImmunologybiology.proteinEtiologyFemaleAntibodybusinessComplex Regional Pain Syndromes

description

The etiology of complex regional pain syndrome (CRPS) is unclear yet. Recently autoantibodies and antecedent viral infections have been discussed to be involved in the pathogenesis of CRPS. We investigated sera from 39 CRPS patients and healthy controls for parvovirus B19 IgG and the occurrence of antiendothelial autoantibodies (AECA). CRPS patients showed a higher seroprevalence of parvovirus B19 IgG than controls (p < 0.01). All CRPS 2 patients were positive. 10.2% of the CRPS patients and 10.0% of the controls had AECA (n.s.) and AECA were not associated with parvovirus B19 seropositivity. Our findings suggest the involvement of parvovirus B19, but not autoantibody-mediated endothelial cell damage, in the pathogenesis of CRPS.

yearjournalcountryeditionlanguage
2005-06-27European Journal of Pain
https://doi.org/10.1016/j.ejpain.2006.01.006