6533b7d8fe1ef96bd126a536

RESEARCH PRODUCT

Novel cytokine-targeted therapies and intestinal inflammation

Markus F. NeurathMarkus F. NeurathMaximilian J. Waldner

subject

medicine.medical_treatmentInflammationTherapeutic targetingInflammatory bowel diseaseAntibodiesPathogenesisDrug Delivery SystemsIntestinal inflammationDrug DiscoverymedicineAnimalsHumansIntestinal MucosaPharmacologyBiological therapiesbusiness.industryModels ImmunologicalColitisInflammatory Bowel Diseasesmedicine.diseasedigestive system diseasesIntestinesClinical trialDisease Models AnimalCytokineImmunologyCytokinesmedicine.symptombusiness

description

Several cytokines have been identified as critical mediators of chronic inflammation in inflammatory bowel disease (IBD) and biological therapies that target these molecules have been developed during recent years. Thereby, anti-TNF agents have noticeably improved the treatment of patients with IBD in comparison to conventional therapy. Furthermore, initial clinical trials showed promising results with anti-IL-6 and anti-IL-12/IL-23 agents. In addition to these well-known mediators of IBD, various novel cytokines have been described as critical during the pathogenesis of IBD in recent experimental studies and therapeutic targeting of these cytokines could provide new strategies for human disease.

yearjournalcountryeditionlanguage
2009-06-12Current Opinion in Pharmacology
https://doi.org/10.1016/j.coph.2009.07.005