6533b7d8fe1ef96bd126abb5

RESEARCH PRODUCT

Opioid-Sensitive Peripheral Neuronal Activity in the Modulation of Gastric Mucosal Injury

B. J. R. WhittleJ. V. Esplugues

subject

business.industryStimulationPharmacologyPeripheralchemistry.chemical_compoundmedicine.anatomical_structureOpioidchemistryCapsaicinAfferentGastric mucosamedicinePremovement neuronal activitybusinessFree nerve endingmedicine.drug

description

There is growing evidence that capsaicin-sensitive afferent neurones participate in the protective mechanisms of the gastric mucosa against damage. Animals pretreated systemically with capsaicin, at doses that lead to the ablation of capsaicin-sensitive afferent neurons, show an increase in the level of macro-scopically apparent mucosal damage in different experimental models of ulceration (Szolcsanyi and Bartho, 1981; Holzer and Sametz, 1986). Furthermore, acute stimulation with capsaicin of afferent nerve endings located in the gastric mucosa protects against different ulcerogenic mechanisms (Szolcsanyi and Bartho, 1981; Holzer and Lippe, 1988; Holzer et al., 1989).

yearjournalcountryeditionlanguage
1991-01-01
https://doi.org/10.1007/978-1-4899-0744-8_12