6533b7d8fe1ef96bd126abc1
RESEARCH PRODUCT
Chemical intervention in senescence-accelerated mice metabolism for modeling neurodegenerative diseases: an overview
Alexander A. BoldyrevAlexander A. BoldyrevTatiana N. FedorovaJose ViñaConsuelo BorrásSergey StvolinskyJuan Sastresubject
Senescencechemistry.chemical_classificationmedicine.medical_specialtyReactive oxygen speciesParkinsonismMPTPCarnosineNeuropeptideGeneral MedicineMetabolismBiologymedicine.disease_causemedicine.diseasechemistry.chemical_compoundEndocrinologyBiochemistrychemistryInternal medicinemedicineOxidative stressdescription
Abstract SAMP1 is a line of inbred mice with a pronounced misbalance between generation and neutralization of reactive oxygen species (ROS) in brain and other tissues. This results in accumulation of molecular defects in lipids, proteins and DNA moieties. The metabolic disorders appear at a very early stage of ontogenic development and induce morphological and behavioral defects manifesting from the fourth month after birth. 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) treatment of these mice induced specific changes that closely resembled parkinsonian syndrome. Neuropeptide carnosine prevented toxic effects of MPTP and protected the animals against experimental parkinsonism.
| year | journal | country | edition | language |
|---|---|---|---|---|
| 2004-02-01 | International Congress Series |