6533b7d8fe1ef96bd126abe8

RESEARCH PRODUCT

Towards a new treatment against polymicrobial infections: high antibacterial activity of lemon IntegroPectin against Pseudomonas aeruginosa and Escherichia coli

Federica ZabiniLorenzo AlbaneseFrancesco MeneguzzoAntonino ScurriaRosaria CiriminnaDomenico NuzzoMario PagliaroPasquale Massimo PiconeAlessandro PresentatoRosa Alduina

subject

biologyPseudomonas aeruginosaChemistryDrug resistancemedicine.disease_causeAntimicrobialbiology.organism_classificationMicrobiologyMinimum inhibitory concentrationmedicineAntibacterial activityEscherichia coliPathogenBacteria

description

AbstractLemon IntegroPectin obtained via hydrodynamic cavitation of waste lemon peel in water only shows high antibacterial activity against two Gram-negative bacteria, Pseudomonas aeruginosa and Escherichia coli. The antibacterial effect against the ubiquitous pathogen P. aeruginosa was evaluated in terms of the minimal bactericidal (MBC) and minimal inhibitory concentration (MIC). Preliminary insight on the antibacterial mechanism of IntegroPectin originates from investigating its inhibitory activity against E. coli. Given the non-cytotoxic nature of citrus IntegroPectin and the ease of its reproducible production in large amounts, the route is open to the industrial development of a new antimicrobial treatment against polymicrobial infections unlikely to develop drug resistance.

yearjournalcountryeditionlanguage
2020-06-17
https://doi.org/10.1101/2020.06.16.154229