0000000000323142

AUTHOR

Federica Zabini

0000-0003-1505-0839

showing 5 related works from this author

Towards a new treatment against polymicrobial infections: high antibacterial activity of lemon IntegroPectin against Pseudomonas aeruginosa and Esche…

2020

AbstractLemon IntegroPectin obtained via hydrodynamic cavitation of waste lemon peel in water only shows high antibacterial activity against two Gram-negative bacteria, Pseudomonas aeruginosa and Escherichia coli. The antibacterial effect against the ubiquitous pathogen P. aeruginosa was evaluated in terms of the minimal bactericidal (MBC) and minimal inhibitory concentration (MIC). Preliminary insight on the antibacterial mechanism of IntegroPectin originates from investigating its inhibitory activity against E. coli. Given the non-cytotoxic nature of citrus IntegroPectin and the ease of its reproducible production in large amounts, the route is open to the industrial development of a new …

biologyPseudomonas aeruginosaChemistryDrug resistancemedicine.disease_causeAntimicrobialbiology.organism_classificationMicrobiologyMinimum inhibitory concentrationmedicineAntibacterial activityEscherichia coliPathogenBacteria
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A New Water-Soluble Bactericidal Agent for the Treatment of Infections Caused by Gram-Positive and Gram-Negative Bacterial Strains

2020

Grapefruit and lemon pectin obtained from the respective waste citrus peels via hydrodynamic cavitation in water only are powerful, broad-scope antimicrobials against Gram-negative and -positive bacteria. Dubbed IntegroPectin, these pectic polymers functionalized with citrus flavonoids and terpenes show superior antimicrobial activity when compared to commercial citrus pectin. Similar to commercial pectin, lemon IntegroPectin determined ca. 3-log reduction in Staphylococcus aureus cells, while an enhanced activity of commercial citrus pectin was detected in the case of Pseudomonas aeruginosa cells with a minimal bactericidal concentration (MBC) of 15 mg mL&minus

0301 basic medicineMicrobiology (medical)Staphylococcus aureusfood.ingredientPectinlemon030106 microbiology<i>Staphylococcus aureus</i>grapefruitmedicine.disease_causeBiochemistryMicrobiologyArticle03 medical and health sciencesAntibiotic resistancefoodmedicineflavonoidPharmacology (medical)Citrus PectinFood scienceantimicrobial resistanceGeneral Pharmacology Toxicology and PharmaceuticspolyphenolsIntegroPectinMinimum bactericidal concentrationbiologyChemistryPseudomonas aeruginosalcsh:RM1-950food and beveragesAntimicrobialbiology.organism_classificationcitrus pectincarbohydrates (lipids)<i>Pseudomonas aeruginosa</i>polyphenollcsh:Therapeutics. Pharmacology030104 developmental biologyInfectious DiseasesStaphylococcus aureusflavonoidscitrus terpenesPseudomonas aeruginosaStaphylococcus aureucitrus terpeneBacteriaAntibiotics
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Volatile Compounds of Lemon and Grapefruit IntegroPectin

2020

An HS-SPME GC-MS analysis of the volatile compounds adsorbed at the outer surface of lemon and grapefruit pectins obtained via the hydrodynamic cavitation of industrial waste streams of lemon and grapefruit peels in water suggests important new findings en route to understanding the powerful and broad biological activity of these new pectic materials. In agreement with the ultralow degree of esterification of these pectins, the high amount of highly bioactive &alpha

Citrusfood.ingredientPectinlemonPhytochemicalsPharmaceutical SciencegrapefruitArticleIndustrial wasteGas Chromatography-Mass SpectrometryAnalytical Chemistrylcsh:QD241-441chemistry.chemical_compoundAdsorptionfoodLinaloolCitrus paradisilcsh:Organic chemistryDrug Discoveryhydrodynamic cavitation?-terpineolFood sciencePhysical and Theoretical ChemistryIntegroPectinpectinResidue (complex analysis)LimoneneVolatile Organic CompoundsMolecular Structureapplied_chemistryOrganic Chemistrycircular economywaste citrus peelBiosynthetic PathwaysTerpineolchemistryChemistry (miscellaneous)FruitMolecular Medicineα-terpineolGas chromatography–mass spectrometryCitric acidCitrus paradisi
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Superior Antibacterial Activity of Integral Lemon Pectin Extracted via Hydrodynamic Cavitation

2020

Abstract Pectin extracted via hydrodynamic cavitation in water only from waste lemon peel and further isolated via freeze drying displays significant antibacterial activity against Staphylococcus aureus, a Gram positive pathogen which easily contaminates food. The antibacterial effect of the new IntegroPectin is largely superior to that of commercial citrus pectin, opening the way to advanced applications of a new bioproduct now obtainable in large amounts and at low cost from citrus juice industry's waste.

CitrusStaphylococcus aureusfood.ingredientPectinAntibacterial effectCITRUS JUICE010402 general chemistrymedicine.disease_cause01 natural scienceslcsh:Chemistrycitrus flavonoidsFreeze-dryingfoodhydrodynamic cavitationmedicineHumansCitrus PectinFood scienceIntegroPectinpectinWaste ProductsLemon peel010405 organic chemistryChemistryPlant ExtractsCommunicationfood and beveragesGeneral ChemistryCommunications0104 chemical sciencesAnti-Bacterial AgentsFruit and Vegetable Juicesantibacteriallcsh:QD1-999Staphylococcus aureusFruitHydrodynamicsPectinsAntibacterial activityChemistryOpen
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Flavonoids in Lemon and Grapefruit IntegroPectin

2021

Abstract Following the analysis of terpenes present in new lemon and grapefruit “IntegroPectin” pectins obtained via the hydrodynamic cavitation of industrial lemon and grapefruit processing waste, the HPLC‐MS analysis of flavonoid and other phenolic compounds reveals the presence of eriocitrin, naringin, hesperidin and kaempferol typical of the respective citrus fruits. The pectic fibers rich in rhamnogalacturonan‐I regions act as chemical sponges adsorbing and concentrating at their outer surface highly bioactive citrus flavonoids and terpenes. These findings, together with the unique molecular structure of these new whole citrus pectins, provide preliminary insight into the broad‐scope b…

Citrusfood.ingredientPectinFlavonoidcitrus fruitsTerpenepectinschemistry.chemical_compoundHesperidinfoodhydrodynamic cavitationFood scienceQD1-999NaringinIntegroPectinFlavonoidschemistry.chemical_classificationFull Paperfood and beveragesNeurodegenerative DiseasesGeneral ChemistryFull Papersfood_chemistryChemistrychemistryFruitEriocitrinKaempferolCitrus paradisi
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