6533b854fe1ef96bd12af3c4

RESEARCH PRODUCT

A New Water-Soluble Bactericidal Agent for the Treatment of Infections Caused by Gram-Positive and Gram-Negative Bacterial Strains

Delia Francesca Chillura MartinoMario PagliaroFederica ZabiniAntonino ScurriaRosa AlduinaRosaria CiriminnaLorenzo AlbaneseDomenico NuzzoFrancesco MeneguzzoElena PiacenzaAlessandro Presentato

subject

0301 basic medicineMicrobiology (medical)Staphylococcus aureusfood.ingredientPectinlemon030106 microbiology<i>Staphylococcus aureus</i>grapefruitmedicine.disease_causeBiochemistryMicrobiologyArticle03 medical and health sciencesAntibiotic resistancefoodmedicineflavonoidPharmacology (medical)Citrus PectinFood scienceantimicrobial resistanceGeneral Pharmacology Toxicology and PharmaceuticspolyphenolsIntegroPectinMinimum bactericidal concentrationbiologyChemistryPseudomonas aeruginosalcsh:RM1-950food and beveragesAntimicrobialbiology.organism_classificationcitrus pectincarbohydrates (lipids)<i>Pseudomonas aeruginosa</i>polyphenollcsh:Therapeutics. Pharmacology030104 developmental biologyInfectious DiseasesStaphylococcus aureusflavonoidscitrus terpenesPseudomonas aeruginosaStaphylococcus aureucitrus terpeneBacteria

description

Grapefruit and lemon pectin obtained from the respective waste citrus peels via hydrodynamic cavitation in water only are powerful, broad-scope antimicrobials against Gram-negative and -positive bacteria. Dubbed IntegroPectin, these pectic polymers functionalized with citrus flavonoids and terpenes show superior antimicrobial activity when compared to commercial citrus pectin. Similar to commercial pectin, lemon IntegroPectin determined ca. 3-log reduction in Staphylococcus aureus cells, while an enhanced activity of commercial citrus pectin was detected in the case of Pseudomonas aeruginosa cells with a minimal bactericidal concentration (MBC) of 15 mg mL&minus

yearjournalcountryeditionlanguage
2020-09-01Antibiotics
10.3390/antibiotics9090586http://europepmc.org/articles/PMC7558503