6533b7d8fe1ef96bd126ac73

RESEARCH PRODUCT

Local H2-Clearance and PO2-Measurements in Microareas of the Brain Tissue in Rats

subject

description

Lubbers [5], as well as others, measured the oxygen partial pressure of the exposed cerebral cortex by means of small platinum microelectrodes. They registered low pO2 values between 1 and 3 mmHg in certain areas of the cortex, despite the fact that the EEG was of normal pattern. In order to decide whether these low pO2 values are a result of low rCBF, or high local oxygen consumption of brain tissue, we developed a new method. Using the same platinum needle, we measured both local pO2 values and H2-clearance curves in microareas of the brain tissue. Cater and Silver [2], Lubbers [4, 5], and others used glass-insulated platinum microelectrodes to measure local pO2. Further, Aukland, Bower and Berliner [1], Lubbers [4, 5], and others employed such electrodes for recording H2-clearance curves. Combining these 2 methods, we are now able to measure local pO2 and local blood flow, with the same microelectrode.