6533b7d8fe1ef96bd126adc4

RESEARCH PRODUCT

The Phenotypic Characterization of the Cammalleri Sisters, an Example of Exceptional Longevity

Anna AielloPaolo ColombaGiulia AccardiMarcello CiaccioImmaculata De VivoDamiano GalimbertiStefano AprileCaterina Maria GambinoCalogero CarusoCiriaco CarruGiuseppina CandoreRosalia CaldarellaGiuseppe CammarataSonya VastoMattia Emanuela LigottiAngelo ZinelluSergio DavinelliSergio Davinelli

subject

0301 basic medicineAgingmedia_common.quotation_subjectBiology03 medical and health sciences0302 clinical medicinelongevityRelative resistanceCause of DeathsemisupercentenarianHumansoxidative stressEpigeneticsmedia_commonAged 80 and overGeneticsoxidative streSiblingsLongevitysupercentenarianPhenotypePhenotype030104 developmental biologyinflammationFemaleGeriatrics and GerontologyCentenarian030217 neurology & neurosurgery

description

This article shows demographic, clinical, anamnestic, cognitive, and functional data as well as biochemical, genetic, and epigenetic parameters of two exceptional siblings: Diega (supercentenarian) and Filippa (semisupercentenarian) Cammalleri. The purpose of this study is to provide new insights into the extreme phenotypes represented by semisupercentenarians and supercentenarians. Different studies have been published on supercentenarians, but to the best of our knowledge, this is the only concerning two sisters and the most detailed from a phenotypic point of view. Our findings agree with the suggestion that supercentenarians have an increasing relative resistance to age-related diseases, approximating the limits of the functional human reserve to address successfully the acute causes of death. More interestingly, our data agree with, and extend, the suggestion that inflammation and oxidative stress predict centenarian mortality.

https://doi.org/10.1089/rej.2019.2299