6533b7d8fe1ef96bd126adf7

RESEARCH PRODUCT

Possible Transmission Flow of SARS-CoV-2 Based on ACE2 Features

Kenneth LundstromNima RezaeiShinjini GhoshPabitra Pal ChoudhuryParise AdadiTarek Mohamed Abd El-azizKazuo TakayamaRamesh KandimallaMurtaza M. TambuwalaGiorgio PalùSk. Sarif HassanVladimir N. UverskyWagner Baetas-da-cruzMurat SeyranGaurav ChauhanGajendra Kumar AzadAdam BrufskySamendra P. SherchanAntonio G. SoaresAlaa A. A. AljabaliDiksha AttrishBruce D. UhalDamiano PizzolÁNgel Serrano-aroca

subject

Pan troglodytesvirusesProtein domainACE2Pharmaceutical ScienceBiologyArticleAnalytical Chemistrylcsh:QD241-44103 medical and health sciencesDogs0302 clinical medicineProtein DomainsSpecies Specificitylcsh:Organic chemistryDrug DiscoveryAnimalsHumansviral spike receptor-binding domainPhysical and Theoretical ChemistryReceptor030304 developmental biologychemistry.chemical_classification0303 health sciencesCATSSARS-CoV-2Transmission (medicine)fungiOrganic ChemistrytransmissionCOVID-19virus diseasesbioinformaticsMetabolismVirologyAmino acidEnzymechemistryChemistry (miscellaneous)030220 oncology & carcinogenesisSpike Glycoprotein CoronavirusAngiotensin-converting enzyme 2CatsMolecular MedicineCattleAngiotensin-Converting Enzyme 2hormones hormone substitutes and hormone antagonists

description

Angiotensin-converting enzyme 2 (ACE2) is the cellular receptor for the Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) that is engendering the severe coronavirus disease 2019 (COVID-19) pandemic. The spike (S) protein receptor-binding domain (RBD) of SARS-CoV-2 binds to the three sub-domains viz. amino acids (aa) 22&ndash

yearjournalcountryeditionlanguage
2020-12-01Molecules
https://doi.org/10.3390/molecules25245906