6533b7d8fe1ef96bd126aec4
RESEARCH PRODUCT
Selective depression of interferon-γ and granulysin production with increase of proliferative response by Vγ9/Vδ2 T cells in children with tuberculosis
Amelia RomanoNadia CaccamoGuido SireciAnnalisa BareraAlfredo SalernoAlfredo SalernoCaterina Di SanoAntonia Accardo-palumboAlan M. KrenskyFrancesco DieliLucina TitonePaola Di Carlosubject
Antigens Differentiation T-LymphocyteMaleAdolescentTuberculosiT cellT-LymphocytesAntitubercular AgentsMycobacterium tuberculosis.BiologyMycobacterium tuberculosisAntitubercular AgentInterferon-gammaImmune systemAntigenmedicineImmunology and AllergyCytotoxic T cellHumansTuberculosisInterferon gammaGranulysinChildTuberculin TestInfantReceptors Antigen T-Cell gamma-deltaMycobacterium tuberculosisbiology.organism_classificationInfectious Diseasesmedicine.anatomical_structureGranulysin productionT-LymphocyteChild PreschoolImmunologyFemalemedicine.drugHumandescription
Vgamma9/Vdelta2 T cells can contribute to protective immune response against Mycobacterium tuberculosis, although the extent to which and mechanisms by which they could actually protect against human tuberculosis remain unclear. We have previously reported that Vgamma9/Vdelta2 T cells from tuberculin purified protein derivative (PPD)-positive children, either healthy or affected by different clinical forms of tuberculosis, strongly proliferate to different phosphoantigens in vitro, whereas Vgamma9/Vdelta2 T cells from PPD-negative healthy subjects proliferate very poorly. We report here that Vgamma9/Vdelta2 T cells from tuberculous children have an increased proliferative activity, but decreased interferon (IFN)-gamma production and granulysin expression. After successful chemotherapy, the Vgamma9/Vdelta2 T cell proliferative response strongly decreased, whereas IFN-gamma and granulysin production consistently increased. Disease-associated changes in Vgamma9/Vdelta2 T cell effector functions in patients with tuberculosis are consistent with the possibility that these T cells may play a protective role in immune response against M. tuberculosis infection.
year | journal | country | edition | language |
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2002-12-15 |