6533b7d8fe1ef96bd126af93
RESEARCH PRODUCT
Synthesis of β- and γ-carbolines via ruthenium and rhodium catalysed [2+2+2] cycloadditions of yne-ynamides with methylcyanoformate
Carole AlayracCarole AlayracBernhard WitulskiBernhard WitulskiFelix NissenVincent Richardsubject
Formateschemistry.chemical_elementRutheniumCatalysisRhodiumCatalysischemistry.chemical_compoundTransition metalReaction sequenceMaterials ChemistryOrganic chemistryRhodiumNatural productMetals and AlloysTotal synthesisGeneral ChemistryCombinatorial chemistryCycloadditionSurfaces Coatings and FilmsElectronic Optical and Magnetic MaterialsRutheniumchemistryCyclizationAlkynesCeramics and CompositesCarbolinesdescription
A flexible approach towards substituted β- and γ-carbolines based on transition metal catalysed [2+2+2] cycloaddition reactions between functionalised yne-ynamides and methylcyanoformate is described. The versatility of this new reaction sequence is demonstrated by its application in the total synthesis of the marine natural product eudistomin U.
| year | journal | country | edition | language |
|---|---|---|---|---|
| 2011-04-21 | Chemical Communications |