6533b7d8fe1ef96bd126b5d1
RESEARCH PRODUCT
Oxidative stress and mitochondrial failure in the pathogenesis of glaucoma neurodegeneration
Vicente Zanon-morenoMaria D Pinazo-duranJose Javier Garcia-medinaRoberto Gallego-pinazosubject
chemistry.chemical_classificationReactive oxygen speciesNeurodegenerationExcitotoxicityMitochondrionBiologymedicine.diseasemedicine.disease_causeNeuroprotectionCell biologyLipid peroxidationchemistry.chemical_compoundchemistryBiochemistryApoptosismedicineOxidative stressdescription
This review focuses on oxidative stress and mitochondrial failure for understanding mechanisms of optic nerve damage in primary open-angle glaucoma. The chapter shows scientific evidence for the role of mitochondrial disbalance and reactive oxygen species in glaucoma neurodegeneration. Mitochondria regulate important cellular functions including reactive oxygen species generation and apoptosis. Mitochondrial alterations result from a wide variety of damaging sources. Reactive oxygen species formed by the mitochondria can act as signaling molecules, inducing lipid peroxidation and/or excitotoxicity with the result of cell lesion and death. Antioxidants may help to counteract oxidative stress and to promote neuroprotection. We provide information that may lead to a new way for diagnosing and treating glaucoma patients.
| year | journal | country | edition | language |
|---|---|---|---|---|
| 2015-01-01 |