6533b7d8fe1ef96bd126b6d0
RESEARCH PRODUCT
Melanin-concentrating hormone axons, but not orexin or tyrosine hydroxylase axons, innervate the claustrum in the rat: An immunohistochemical study
Gabrielle FranchiPierre-yves RisoldChristophe HoudayerFabrice PoncetMarie Barbiersubject
0301 basic medicineExternal capsuleLateral hypothalamusTyrosine hydroxylaseGeneral NeuroscienceBiologyClaustrumMidbrain03 medical and health sciences030104 developmental biology0302 clinical medicinemedicine.anatomical_structurenervous systemCerebral cortexmedicineBrainstemNucleusNeurosciencehormones hormone substitutes and hormone antagonists030217 neurology & neurosurgerydescription
The claustrum is a small, elongated nucleus close to the external capsule and deep in the insular cortex. In rodents, this nucleus is characterized by a dense cluster of parvalbumin labeling. The claustrum is connected with the cerebral cortex. It does not project to the brainstem, but brainstem structures can influence this nucleus. To identify some specific projections from the lateral hypothalamus and midbrain, we analyzed the distribution of projections labeled with antibodies against tyrosine hydroxylase (TH), melanin-concentrating hormone (MCH), and hypocretin (Hcrt) in the region of the claustrum. The claustrum contains a significant projection by MCH axons, whereas it is devoid of TH projections. Unlike TH and MCH axons, Hcrt axons are scattered throughout the region. This observation is discussed mainly with regard to the role of the claustrum in cognitive functions and that of MCH in REM sleep. J. Comp. Neurol. 525:1489-1498, 2017. © 2016 Wiley Periodicals, Inc.
| year | journal | country | edition | language |
|---|---|---|---|---|
| 2016-10-21 | Journal of Comparative Neurology |