6533b7d8fe1ef96bd126b6f5

RESEARCH PRODUCT

Effects of two selective dopaminergic antagonists on ethologically-assessed encounters in male mice

A. AzpirozPaul F. BrainVicente M. SimónAmaia Arregui

subject

Malemedicine.medical_specialtySpiperoneMotor ActivityPharmacologyReceptors DopamineMicechemistry.chemical_compoundDopamine receptor D1Internal medicineDopamine receptor D2medicineAnimalsReceptorPharmacologySCH-23390business.industryAggressionAntagonistDopamine antagonistBenzazepinesAggressionEndocrinologychemistrySpiperonemedicine.symptombusinessmedicine.drug

description

Abstract 1. Although it is accepted that dopaminergic antagonists suppress aggressive behaviour, the drugs used have been relatively non-selective or specific to the D2 receptor. 2. The selective D1 antagonist, SCH 23390, makes it possible to evaluate the impact of this receptor on aggressive behaviour. 3. The effects of SCH 23390 and Spiperone (a D2 antagonist) on the aggressive behaviour of mice were assessed employing a “standard opponent” test. 4. Both drugs markedly decreased aggressive behaviour whilst increasing immobility. However, whilst SCH 23390 increased immobility to a small extent, Spiperone, produced a general decline in active behaviours. 5. It appears that the D1 receptor inhibition of aggression is the more specific.

yearjournalcountryeditionlanguage
1993-03-01General Pharmacology: The Vascular System
https://doi.org/10.1016/0306-3623(93)90316-p