6533b7d8fe1ef96bd126b755

RESEARCH PRODUCT

Chronic occupational noise exposure: Effects on DNA damage, blood pressure, and serum biochemistry

Majid Bagheri HosseinabadiAndreas DaiberNarges KhanjaniMohammad YaghmorlooThomas Münzel

subject

AdultMaleSerum0301 basic medicineDNA damageHealth Toxicology and MutagenesisPhysiologyBlood PressureIran010501 environmental sciencesmedicine.disease_cause01 natural sciencesPeripheral blood mononuclear cellYoung Adult03 medical and health scienceschemistry.chemical_compoundOccupational ExposureGeneticsmedicineHumansIndustry0105 earth and related environmental scienceschemistry.chemical_classificationGlutathione Peroxidasebiologybusiness.industryGlutathione peroxidaseCeruloplasminGlutathioneMiddle AgedComet assay030104 developmental biologyBlood pressurechemistryLeukocytes MononuclearNoise Occupationalbiology.proteinComet AssayCeruloplasminbusinessOxidative stressDNA Damage

description

Abstract Noise levels experienced by industrial workers may cause both auditory and non-auditory harmful effects. We have studied the effects of chronic industrial noise exposure on DNA damage, blood pressure, and serum biochemistry in factory workers. Male workers (109 individuals) in three parts of a food factory in Shahroud, Iran were enrolled as the exposed group and male office workers (123 individuals) were the unexposed control group. Noise exposure was measured (dosimetry) and the comet assay was used to evaluate DNA damage in peripheral blood mononuclear cells. Glutathione peroxidase (GPx) and ceruloplasmin (Cp) levels were measured in serum samples. GPx levels, systolic and diastolic blood pressure, and DNA damage were significantly higher in the exposed group than in the control group. However, ceruloplasmin levels were not significantly different. Based on multivariate linear regression analysis, noise exposure was the most important predictor of GPx levels, systolic and diastolic blood pressure, and DNA damage.

yearjournalcountryeditionlanguage
2019-05-01Mutation Research/Genetic Toxicology and Environmental Mutagenesis
https://doi.org/10.1016/j.mrgentox.2019.04.006