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RESEARCH PRODUCT
Synthesis, Optical Properties, and DNA Interaction of New Diquats Based on Triazolopyridines and Triazoloquinolines
Ramón J. ZaragozáBelén AbarcaM. José AurellRafael BallesterosEnrique García-españaRafael Ballesteros-garridoClaudia GiarratanoPedro J. Llabres-campanerLluis Guijarrosubject
Models MolecularMagnetic Resonance SpectroscopyStatic ElectricityIntercalation (chemistry)Molecular Conformation010402 general chemistryPhotochemistry01 natural sciencesMedicinal chemistryCatalysischemistry.chemical_compoundUltraviolet visible spectroscopyPyridineDiquatAlkylchemistry.chemical_classificationAlkane010405 organic chemistryQuinolinium CompoundsOrganic ChemistryQuinolineStereoisomerismDNAGeneral ChemistryTriazolesFluorescenceIntercalating Agents0104 chemical sciencesPyrimidineschemistrySpectrophotometryThermodynamicsEnantiomerdescription
New diquat derivatives based on [1,2,3]triazolo[1,5-a]pyridine and [1,2,3]triazolo[1,5-a]quinoline have been synthesized in excellent yields. To evaluate the effect of the alkyl bridge length, ethane and propane dibromo alkane substrates were used for their synthesis. Theoretical calculations predicted a very small energetic barrier between the two possible enantiomers P (Ra ) and M (Sa ), which makes them very difficult to resolve. Thermal denaturation studies, UV/Visible spectroscopy, and fluorescence titrations with ct-DNA evidenced the intercalation of the quinoline derivatives in DNA.
| year | journal | country | edition | language |
|---|---|---|---|---|
| 2017-04-11 | Chemistry - A European Journal |