6533b7d8fe1ef96bd126b7ce

RESEARCH PRODUCT

Capillary Liquid Chromatography for the Determination of Terpenes in Botanical Dietary Supplements

Pilar Campíns-falcóJorge Verdú-andrésHenry Daniel Ponce-rodríguezRosa Herráez-hernández

subject

Farnesenenatural productsPharmaceutical ScienceOrange (colour)01 natural sciencesArticleTerpenedietary supplementschemistry.chemical_compoundPharmacy and materia medica0404 agricultural biotechnologyLinaloolDrug DiscoveryLimoneneChromatography010401 analytical chemistryR04 agricultural and veterinary sciencesplant materials040401 food sciencecapillary liquid chromatography0104 chemical sciencesRS1-441chemistryMyrceneGreen coffee extractMedicineMolecular MedicineGas chromatographyterpenes

description

Dietary supplements of botanical origin are increasingly consumed due to their content of plant constituents with potential benefits on health and wellness. Among those constituents, terpenes are gaining attention because of their diverse biological activities (anti-inflammatory, antibacterial, geroprotective, and others). While most of the existing analytical methods have focused on establishing the terpenic fingerprint of some plants, typically by gas chromatography, methods capable of quantifying representative terpenes in herbal preparations and dietary supplements with combined high sensitivity and precision, simplicity, and high throughput are still necessary. In this study, we have explored the utility of capillary liquid chromatography (CapLC) with diode array detection (DAD) for the determination of different terpenes, namely limonene, linalool, farnesene, α-pinene, and myrcene. An innovative method is proposed that can be applied to quantify the targets at concentration levels as low as 0.006 mg per gram of sample with satisfactory precision, and a total analysis time &lt

yearjournalcountryeditionlanguage
2021-06-01Pharmaceuticals
10.3390/ph14060580http://dx.doi.org/10.3390/ph14060580