Papaverine enhances the negative inotropic effect of acetylcholine in rat auricles

6533b7d8fe1ef96bd126b82a

RESEARCH PRODUCT

Papaverine enhances the negative inotropic effect of acetylcholine in rat auricles

subject

Inotrope medicine.medical_specialty Action Potentials In Vitro Techniques Cellular and Molecular Neuroscience Papaverine Internal medicine medicine Animals Heart Atria Phosphodiesterase inhibitor Cyclic GMP Molecular Biology Pharmacology Papaverine Chemistry Phosphodiesterase Drug Synergism Cell Biology Myocardial Contraction Acetylcholine Rats Endocrinology Depression Chemical Molecular Medicine Acetylcholine medicine.drug

description

The negative inotropic effect of acetylcholine in rat left auricles is enhanced in the presence of the phosphodiesterase inhibitor papaverine. This result favours the idea of a cyclic GMP-mediated action of acetylcholine in the heart.

year	journal	country	edition	language
1978-07-01	Experientia

https://doi.org/10.1007/bf01939666

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