6533b7d8fe1ef96bd126b841
RESEARCH PRODUCT
Acute Cerebrovascular Disease in the Young
Arndt RolfsFranz FazekasUlrike GrittnerMartin DichgansPeter MartusMartin HolzhausenTobias BöttcherPeter U. HeuschmannTurgut TatlisumakChristian TanislavGerhard J. JungehulsingAnne-katrin GieseJukaa PutaalaRoman HuberUlf BodechtelChristoph LichyChristian EnzingerReinhold SchmidtMichael G. HennericiManfred KapsChristof KesslerKarl LacknerEduard PaschkeWolfgang MeyerHermann MascherOlaf RiessEdwin KolodnyBo NorrvingA RolfsM GinsbergMg HennericiC KesslerE KolodnyP MartusB NorrvingEb RingelsteinPm RothwellG VenablesN BornsteinP DedeynM DichgansF FazekasH MarkusO RießC BiedermannT BöttcherK BrüderleinJ BurmeisterI FederowF KönigG MakoweiD NiemannA RolfsS RösnerS ZielkeU GrittnerP MartusM HolzhausenF FazekasC EnzingerR SchmidtS RopeleM WindischE SternerO BodamerA FellgiebelU HillenL JonasC KampmannP KroppK LacknerM LaueH MascherW MeyerE PaschkeF WeidemannJ BerrouschotA StollA RokichaC SternitzkyM ThomäPp DedeynR SheorajpandayI De BrabanderL YperzeeleR BrounsP OschmannM PottK SchultesC SchultzeJ HirsekornGj JungehulsingA VillringerW SchmidtT LimanT NoweM EbingerA WilleH LouiA ObjartelA üBelackerR MetteK JegzentisDg NabaviO CromeD BahrM EbkeB PlatteC KleinenK Mermolja GuntherW HeideO PapeJr HanssenD StangenbergJ KlingelhoferB SchmidtS SchwarzJ SchwarzeL FrandlihJ IwanowI SteinbachD KriegerG BoysenL Leth JeppesenA PetersenH ReichmannU BeckerI DzialkowskiH HentschelC LautenschlagerH HansoG GahnT ZiemssenK FleischerB SehrDjh MccabeO TobinJ KinsellaRp MurphyS JanderHp HartungM SieblerC BottcherA KohneJ PlatzenTc BrosigV RothhammerC HenselerT Neumann-haefelinOc SingerU ErmisImrm Dos SantosC SchuhmannS Van De LooM KapsJ AllendorferC TanislavM BrandtnerK MuirK DaniN MacdougallW SmithA RoweA WelchF FazekasG SchrotterU KrennS HornerB PendlA Pluta-fuerstU TrummerC KesslerM ChatzopoulosBettina V SarnowskiUlf SchminkeT LinkA KhawE NieberS ZierzT MullerN WegenerK WartenbergC GaulD RichterM RosenkranzAc KrützelmannJ HoppeCu ChoeS NarrTu MagnusG ThomallaF LeypoldtD OttoC LichyW HackeRj BarrowsT TatlisumakJ PutaalaS CurtzeM MetsoJ WilleitM FurtnerM SpiegelMh KnoflachB PrantlOw WitteD BrämerA GüntherT PrellC HerzauK AurichG DeuschlF WodargP ZimmermannCc EschenfelderM LevsenJr WeberSm MarecekD SchneiderD MichalskiW KloppigL Küppers-tiedtM SchneiderA SchulzP MatzenC WeiseC HobohmH MeierR LangosD UrbanI GerhardtV ThijsR LemmensE MarcelisC HulsboschF AichnerHp HaringE BachJ Machado CandidoAa E SilvaM LourencoAim De SousaL DerexTh ChoE Díez-tejedorB FuentesP Martínez-sanchezMi Pérez-guevaraH HamerA MetzK HallenbergerP MüllerP BaronA BersanoM GattinoniN VellaM MalliaM JaussL AdamF HeidlerC GubeM KiszkaM DichgansA KarpinskaY MewaldV StraubA DörrA ZollverEb RingelsteinM SchillingA BorchertN PreuthT DuningG KuhlenbäumerD SchultePm RothwellL MarquardtF SchlachetzkiS BoyJ MädlGm ErtlNpr FehmC StadlerR BeneckeA DudesekS KolbaskeG LardurnerC SulzerA ZerbsS LilekAm WalleczekD SinadinowskaM JanelidzeM BeridzeN LobjanidzeA DzagnidzeA MelmsK HorberI FinkB LiskeAc LudolphR HuberK KnauerC HendrichS RauboldA CzlonkowskaA BaranowskaB Blazejewska-hyzorekW LangW KristoferitschJ FerrariE UlrichA Flamm-horakA Lischka-lindnerW SchreiberV DemarinZ TranjecM Bosner-pureticMj JurašićV Basic KesM BudisicL Kopacevicsubject
AdultMalemedicine.medical_specialtyPediatricsAdolescentischemiccauseCohort StudiesYoung AdultRisk FactorsmedicineHumansrisk factorsProspective Studiescardiovascular diseasesYoung adultProspective cohort studyStrokeAdvanced and Specialized NursingIntracerebral hemorrhageFabry diseaseCerebral infarctionbusiness.industryAge Factorsimagingyoung strokeMiddle Agedmedicine.diseaseintracerebral hemorrhagestrokeFabry diseaseEuropeStrokeCerebrovascular DisordersNeurologytransient ischemic attackAcute DiseaseCohortPhysical therapyFabry DiseaseFemaleNeurology (clinical)Cardiology and Cardiovascular MedicinebusinessCohort studydescription
Background and Purpose— Strokes have especially devastating implications if they occur early in life; however, only limited information exists on the characteristics of acute cerebrovascular disease in young adults. Although risk factors and manifestation of atherosclerosis are commonly associated with stroke in the elderly, recent data suggests different causes for stroke in the young. We initiated the prospective, multinational European study Stroke in Young Fabry Patients (sifap) to characterize a cohort of young stroke patients. Methods— Overall, 5023 patients aged 18 to 55 years with the diagnosis of ischemic stroke (3396), hemorrhagic stroke (271), transient ischemic attack (1071) were enrolled in 15 European countries and 47 centers between April 2007 and January 2010 undergoing a detailed, standardized, clinical, laboratory, and radiological protocol. Results— Median age in the overall cohort was 46 years. Definite Fabry disease was diagnosed in 0.5% (95% confidence interval, 0.4%–0.8%; n=27) of all patients; and probable Fabry disease in additional 18 patients. Males dominated the study population (2962/59%) whereas females outnumbered men (65.3%) among the youngest patients (18–24 years). About 80.5% of the patients had a first stroke. Silent infarcts on magnetic resonance imaging were seen in 20% of patients with a first-ever stroke, and in 11.4% of patients with transient ischemic attack and no history of a previous cerebrovascular event. The most common causes of ischemic stroke were large artery atherosclerosis (18.6%) and dissection (9.9%). Conclusions— Definite Fabry disease occurs in 0.5% and probable Fabry disease in further 0.4% of young stroke patients. Silent infarcts, white matter intensities, and classical risk factors were highly prevalent, emphasizing the need for new early preventive strategies. Clinical Trial Registration Information— URL: http://www.clinicaltrials.gov .Unique identifier: NCT00414583
| year | journal | country | edition | language |
|---|---|---|---|---|
| 2013-01-01 | Stroke |