6533b7d8fe1ef96bd126b874

RESEARCH PRODUCT

Iontophoretic Transdermal Delivery of Sumatriptan: Effect of Current Density and Ionic Strength

Alicia López-castellanoA. Femenía-fontVirginia MerinoC. Balaguer-fernández

subject

OsmosisTime FactorsSwineSkin AbsorptionDiffusionPharmaceutical ScienceBuffersSodium ChloridePharmacologyAdministration CutaneousPharmaceutical technologymedicineAnimalsSkinTransdermalIontophoresisSumatriptanChemistryOsmolar ConcentrationEarIontophoresisLow ionic strengthSerotonin Receptor AgonistsSumatriptanIonic strengthCurrent densitymedicine.drugBiomedical engineering

description

ABSTRACT: Iontophoretic transdermal delivery of sumatriptan was investigated in vitro . Among the conditions tested, 0.25 mA/cm 2 and low ionic strength (NaCl 25 mM) was the best experimental condition to increase its transport across the skin. The flux increased 385-fold respective to passive diffusion, thus resulting in a transdermal flux of sumatriptan of 1273 ± 83 nmol/cm 2 h. © 2005 Wiley-Liss, Inc. and the American Pharmacists Association

yearjournalcountryeditionlanguage
2005-09-02Journal of Pharmaceutical Sciences
https://doi.org/10.1002/jps.20447