6533b7d8fe1ef96bd126b87c
RESEARCH PRODUCT
Simple and scalable electrochemical synthesis of 2,1-benzisoxazoles and quinoline N-oxides.
Haralds BaunisSiegfried R. WaldvogelEdgars SunaEduardo Rodrigosubject
Electrolysis010405 organic chemistryElectrolytic cellQuinolineMetals and AlloysGeneral Chemistry010402 general chemistryElectrochemistry01 natural sciencesCombinatorial chemistryCatalysis0104 chemical sciencesSurfaces Coatings and FilmsElectronic Optical and Magnetic Materialslaw.inventionchemistry.chemical_compoundchemistrylawReagentMaterials ChemistryCeramics and CompositesNitroConstant currentMoietydescription
Cathodic reduction of the nitro moiety and subsequent intramolecular cyclization affords different substituted 2,1-benzisoxazoles and quinoline N-oxides. This methodology allows the synthesis of two different types of heterocycles from common simple starting materials, using electrons as a sole reagent for this transformation. The electrolysis can be conducted in a very simple undivided electrolysis cell under constant current conditions. This permits working on a larger scale compared to other electrochemical methodologies and represents a significant advantage.
| year | journal | country | edition | language |
|---|---|---|---|---|
| 2019-09-27 | Chemical communications (Cambridge, England) |