6533b7d9fe1ef96bd126b8b3
RESEARCH PRODUCT
Transdermal therapy and diagnosis by iontophoresis
Virginia MerinoYogeshvar N. KaliaRichard H. Guysubject
Drugddc:615Skin Diseases/diagnosis/therapyPeptides/administration & dosageIontophoresisbusiness.industrymedia_common.quotation_subjectBiotechnology/trendsBioengineeringIontophoresis/methodsIontophoresisPharmacologyAdministration CutaneousDiagnostic monitoringSkin DiseasesBlood chemistryOral administrationHumansMedicinePeptidesbusinessBiotechnologymedia_commonTransdermaldescription
Iontophoresis, the use of an electric current to drive charged molecules across the skin, has the potential to expand the feasible range of drugs for transdermal administration significantly. This method of delivery is being examined carefully with respect to higher-molecular-weight therapeutics (in particular, peptides and small proteins), which cannot be absorbed following oral administration and for which, at this time, an invasive injection remains the only option. In addition, the procedure of so-called 'reverse' iontophoresis would appear to represent a truly noninvasive approach for diagnostic monitoring of blood chemistry.
| year | journal | country | edition | language |
|---|---|---|---|---|
| 1997-08-01 | Trends in Biotechnology |