6533b7d9fe1ef96bd126b937
RESEARCH PRODUCT
Crystalloid Lysozyme Inclusions in Paneth Cells of Vitamin A-Deficient Rats
Hans Konrad BiesalskiE. StofftBurkard Schulz-dobrickMartin J. KochHans-p. DienesHarald Weisersubject
MaleVitaminmedicine.medical_specialtyBiologydigestive systemEpitheliumGeneral Biochemistry Genetics and Molecular Biologylaw.inventionRats Sprague-Dawleychemistry.chemical_compoundHistory and Philosophy of SciencelawInternal medicinemedicineAnimalsSecretionMicroscopy ImmunoelectronVitamin A DeficiencyGeneral Neurosciencemedicine.diseaseRatsVitamin A deficiencyMicroscopy ElectronZincJejunumEndocrinologyBiochemistrychemistryVacuolesMuramidaseLocal immunityElectron microscopeLysozymeElectron Probe Microanalysisdescription
The effect of vitamin A-deficiency on jejunal Paneth cells in rats was investigated. Crystalloid particles were observed in secretion granules of Paneth cells from 6 out of 8 rats with vitamin A-deficiency. The particles were similar to those found in Paneth cells under other experimental conditions. Using an immuno-electron-microscopic technique we demonstrated a clear lysozyme immunoreactivity of these particles. In 2 vitamin A-deficient rats tubular structures have been detected in addition to the crystalloid particles. Crystalloid particles or tubular structures were not detectable in a control group of 8 vitamin A-supplemented rats. The morphological alterations of Paneth cells may be correlated to an impaired local immunity of the intestine during vitamin A-deficiency.
| year | journal | country | edition | language |
|---|---|---|---|---|
| 1992-09-01 | Annals of the New York Academy of Sciences |