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RESEARCH PRODUCT
Cardiac Stem Cell Research: An Elephant in the Room?
Filippo MacalusoAngela De LucaA MontalbanoNella Maria ArdizzoneValentina Di FeliceMaria Luisa ColoritoAntonella Marino GammazzaFrancesco CappelloGiovanni Zummosubject
Pathologymedicine.medical_specialtyHistologyHeart Diseasesmedicine.medical_treatmentCD34heart failureStem-cell therapyBiologyEmbryonic stem cellCell therapyEmbryo ResearchAmniotic epithelial cellsmedicineHumanscardiac immature cellcell therapyAnatomyStem cellEmbryonic Stem CellsEcology Evolution Behavior and SystematicsStem Cell TransplantationBiotechnologyAdult stem cellStem cell transplantation for articular cartilage repairdescription
Heart disease is the leading cause of death in the industrialized world, and stem cell therapy seems to be a promising treatment for injured cardiac tissue. To reach this goal, the scientific community needs to find a good source of stem cells that can be used to obtain new myocardium in a very period range of time. Since there are many ethical and technical problems with using embryonic stem cells as a source of cells with cardiogenic potential, many laboratories have attempted to isolate potential cardiac stem cells from several tissues. The best candidates seem to be cardiac "progenitor" and/or "stem" cells, which can be isolated from subendocardial biopsies from the same patient or from embryonic and/or fetal myocardium. Regardless of the technique used to isolate and characterize these cells, it appears that the different cells isolated from adult myocardium to date are all phenotypic variations of a unique cell type that expresses several markers, such as c-Kit, CD34, MDR-1, Sca-1, CD45, nestin, or Isl-1, in various combinations.
| year | journal | country | edition | language |
|---|---|---|---|---|
| 2009-01-01 | The Anatomical Record: Advances in Integrative Anatomy and Evolutionary Biology |