Multiple Myeloma-Derived Extracellular Vesicles Induce Osteoclastogenesis through the Activation of the XBP1/IRE1α Axis

6533b7d9fe1ef96bd126b99c

RESEARCH PRODUCT

Multiple Myeloma-Derived Extracellular Vesicles Induce Osteoclastogenesis through the Activation of the XBP1/IRE1α Axis

Viviana Costa Stefania Raimondo Nicola Amodio Milena Fini Francesca Monteleone Sergio Siragusa Angela De Luca Gianluca Giavaresi Valeria Carina Lavinia Raimondi Simona Fontana Riccardo Alessandro Riccardo Alessandro Daniele Bellavia

subject

0301 basic medicine Cancer Research Cell signaling XBP1 Cellular differentiation lcsh:RC254-282 Article 03 medical and health sciences 0302 clinical medicine Settore BIO/13 - Biologia Applicata Transcription factor Chemistry Endoplasmic reticulum extracellular-vesicles Extracellular vesicle lcsh:Neoplasms. Tumors. Oncology. Including cancer and carcinogens Cell biology multiple myeloma UPR-related molecules 030104 developmental biology osteoclasts Oncology 030220 oncology & carcinogenesis Unfolded protein response Phosphorylation bone disease

description

Bone disease severely affects the quality of life of over 70% of multiple myeloma (MM) patients, which daily experience pain, pathological fractures, mobility issues and an increased mortality. Recent data have highlighted the crucial role of the endoplasmic reticulum-associated unfolded protein response (UPR) in malignant transformation and tumor progression

year	journal	country	edition	language
2020-08-04	Cancers

10.3390/cancers12082167 http://europepmc.org/articles/PMC7465175

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