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RESEARCH PRODUCT
Bifunctional Gallium-68 Chelators: Past, Present, and Future
Philipp SpangFrank RoeschChristian Herrmannsubject
Macrocyclic CompoundsRadiochemistry010405 organic chemistrybusiness.industrychemistry.chemical_elementGallium Radioisotopes010402 general chemistry01 natural sciencesCombinatorial chemistry0104 chemical scienceschemistry.chemical_compoundchemistryBifunctional chelateMedicineRadiology Nuclear Medicine and imagingChelationGalliumbusinessBifunctionalChelating Agentsdescription
This article reviews the development of bifunctional chelates for synthesising (68)Ga radiopharmaceuticals. It structures the chelates into groups of macrocycles, nonmacrocycles, and chimeric derivatives. The most relevant bifunctional chelates are discussed in chelate structure, parameters of (68)Ga-labeling, and stability of the (68)Ga-chelate complexes. Furthermore those derivatives are included, where (67)Ga was applied instead of (68)Ga. A particular feature discussed is the ability of certain bifunctional chelate structures to function in kit-type preparation of the (68)Ga radiopharmaceuticals. Currently, nonmacrocyclic and chimeric derivates attract particular attention such as THP-derivates and DATA-derivates.
year | journal | country | edition | language |
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2016-08-25 | Seminars in Nuclear Medicine |