6533b7d9fe1ef96bd126ba11
RESEARCH PRODUCT
Incidence, age at onset, and potential reasons of malignant transformation in recurrent respiratory papillomatosis patients: 20 years experience
Wolfgang DrafValentin GereinValentin GereinEugen RastorguevJohann GereinJoachim Schirrensubject
AdultMaleLarynxmedicine.medical_specialtyLung NeoplasmsTime FactorsAdolescentMalignant transformation03 medical and health sciences0302 clinical medicineInternal medicineHumansMedicineProspective StudiesTreatment FailureAge of Onset030223 otorhinolaryngologyProspective cohort studyPapillomaHpv typesbusiness.industryIncidenceIncidence (epidemiology)Disease progressionNasopharyngeal NeoplasmsSurgeryCell Transformation Neoplasticmedicine.anatomical_structureOtorhinolaryngologyChild Preschool030220 oncology & carcinogenesisFemaleSurgeryNeoplasm Recurrence LocalRecurrent Respiratory PapillomatosisAge of onsetbusinessFollow-Up Studiesdescription
Forty-two patients with recurrent respiratory papillomatosis (RRP) were accepted into a multicenter prospective study in 1983 to 1990, treated with alfa-IFN 3 MU/m 2 3 times a week and then followed-up until August 1, 2003. All the patients who had disease progression with pulmonary spread were characterized by insufficient response to IFN-therapy and detection of HPV type 11. Five patients (4/5 smokers) presented malignant transformation in lungs or nasopharynx (mean RRP duration was 27.2 +/- 8 years from RRP onset and 14.6 +/- 6.3 years from pulmonary spread until malignant transformation) with persistent RRP in larynx. The results of long-term follow-up in RRP patients with HPV 11 underline the necessity of reanalyzing the current therapy.
| year | journal | country | edition | language |
|---|---|---|---|---|
| 2005-03-05 | Otolaryngology–Head and Neck Surgery |