6533b7d9fe1ef96bd126c01d

RESEARCH PRODUCT

Impact of Localized Microwave Hyperthermia on the Oxygenation Status of Malignant Tumors

J. OtteJ. OttePeter VaupelPeter VaupelGerhard ThewsGerhard ThewsR. ManzR. Manz

subject

HyperthermiaProgrammed cell deathHeat inducedCell killingIn vivoChemistryCancer researchmedicineTissue oxygenMicrowave hyperthermiaOxygenationmedicine.disease

description

Considerable insight into the mechanisms of heat induced cell death in vitro has been gained during recent years (for reviews see 1–3). Besides the direct cell killing effect of heat, many microenvironmental or milieu factors seem to play an important role during heat treatment of solid tumors in vivo, such that a preferential effect of hyperthermia on tumors has been postulated for the in situ conditions. Environmental factors affecting the tumor milieu, such as tissue oxygen partial pressures, pH values, glucose (?) and lactate levels, nutrient supply and drainage of wastes, have thus become a subject of topical interest.

yearjournalcountryeditionlanguage
1982-01-01
https://doi.org/10.1007/978-1-4684-4388-2_6