6533b7d9fe1ef96bd126c024

RESEARCH PRODUCT

Determination of promethazine hydrochloride with bromophenol blue by a turbidimetric method and flow injection analysis

S. Navasquillo SarrionJ. Martínez CalatayudA. Sanchez SampedroC. Gómez Benito

subject

Flow injection analysisChromatographyCalibration curvePromethazine HydrochlorideBromophenol bluePharmaceutical formulationAnalytical ChemistryPromethazinechemistry.chemical_compoundchemistryReagentmedicineSpectroscopymedicine.drug

description

Abstract A flow injection analysis procedure for the turbidimetric determination of promethazine is proposed. The sample solution is injected directly into the carrier reagent stream, which is composed of 1.16 × 10 −3 M bromophenol blue at pH 1.20. The calibration graph is linear over the range 25–197 ppm of promethazine. The influence of some foreign substances was also investigated. The method is applied to promethazine determination in a pharmaceutical formulation.

yearjournalcountryeditionlanguage
1992-04-01Microchemical Journal
https://doi.org/10.1016/0026-265x(92)90004-m