0000000000335489
AUTHOR
S. Navasquillo Sarrion
Determination of promethazine hydrochloride with bromophenol blue by a turbidimetric method and flow injection analysis
Abstract A flow injection analysis procedure for the turbidimetric determination of promethazine is proposed. The sample solution is injected directly into the carrier reagent stream, which is composed of 1.16 × 10 −3 M bromophenol blue at pH 1.20. The calibration graph is linear over the range 25–197 ppm of promethazine. The influence of some foreign substances was also investigated. The method is applied to promethazine determination in a pharmaceutical formulation.
Determination of diphenhydramine hydrochloride by flow injection with Bromophenol Blue and turbidimetric measurement
The study of a number of diphenhydramine-dye systems was carried out in order to determine the most suitable precipitate for the turbidimetric determination of diphenhydramine using flow injection (FI). The reagent selected was Bromophenol Blue. The chemical and FI variables were optimised. The calibration graph was linear over the concentration range 50-230 p.p.m. of diphenhydramine hydrochloride. A number of interfering substances were also investigated.