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RESEARCH PRODUCT
Structural Motifs of Alkali Metal Superbases in Non‐coordinating Solvents
Jan Klettsubject
superbasealkali metalschemistry.chemical_element010402 general chemistry01 natural sciencesChemical synthesisCatalysisReactivity (chemistry)Solubility010405 organic chemistrypotassiumOrganic ChemistrySuperbaseaggregationMinireviewsGeneral ChemistryAlkali metalCombinatorial chemistry0104 chemical scienceschemistrylithiumReagentElectrophileLithiumMinireviewOrganometallic Chemistry | Reviews Showcasedescription
Abstract Lochmann–Schlosser superbases (LSB) are a standard reagent in synthetic chemistry to achieve an exchange of a proton on an organic framework with an alkali metal cation, which in turn can be replaced by a wide range of electrophilic groups. In standard examples, the deprotonating reagent consists of an equimolar mixture of n‐butyllithium and potassium t‐butoxide. However, the nature of the reactive species could not be pinned down either for this composition or for similar mixtures with comparable high reactivity. Despite the poor solubility and the fierce reactivity, some insights into this mixture were achieved by some indirect results, comparison with chemically related systems, or skillful deductions. Recent results, mainly based on new soluble compounds, delivered structural evidence. These new insights lead to advanced and more detailed conclusions about the interplay of the involved components.
| year | journal | country | edition | language |
|---|---|---|---|---|
| 2020-11-09 | Chemistry – A European Journal |