6533b7d9fe1ef96bd126c2eb
RESEARCH PRODUCT
Theoretical insight into the intrinsic ultrafast formation of cyclobutane pyrimidine dimers in UV-irradiated DNA: thymine versus cytosine.
Luis Serrano-andrésJuan José Serrano-pérezPedro B. CotoManuela MerchánIsrael González-ramírezsubject
Models MolecularTime FactorsUltraviolet RaysAb initioPyrimidine dimerDNAInternal conversion (chemistry)PhotochemistrySurfaces Coatings and FilmsThymineCyclobutanechemistry.chemical_compoundCytosineMonomerchemistryPyrimidine DimersMaterials ChemistryNucleic Acid ConformationPhysical and Theoretical ChemistryCytosineDNAThymineDNA Damagedescription
The higher formation yields measured in the ultrafast photoinduced formation of cyclobutane thymine dimers (T T) with respect to those of cytosine (C C) are explained, on the basis of ab initio CASPT2 results, by the existence in thymine of more reactive orientations and a less efficient photoreversibility, whereas in cytosine the funnel toward the photolesion becomes competitive with that mediating the internal conversion of the excited-cytosine monomer.
| year | journal | country | edition | language |
|---|---|---|---|---|
| 2008-10-22 | The journal of physical chemistry. B |