6533b7d9fe1ef96bd126c39d
RESEARCH PRODUCT
Cathepsin L in Normal and Pathological Bone Remodeling
Francesca Maria TumminelloMaria Vittoria SepportaMarilena CrescimannoCarla FlandinaGaetano Letosubject
chemistry.chemical_classificationmedicine.medical_specialtybiologyEndocrinology Diabetes and MetabolismBone metastasisBone diseases Bone metastasis Cancer Cathepsin L Cysteine proteinases Proteinase inhibitorsmedicine.diseaseBone resorptionCell biologyBone remodelingCathepsin LEndocrinologyEndocrinologyEnzymechemistryInternal medicinemedicineCathepsin Kbiology.proteinOrthopedics and Sports MedicinePathologicalHomeostasisdescription
Abstract Cathepsin L is a ubiquitous lysosomal cysteine endopeptidase that is mainly involved in the metabolic turnover of intracellular proteins. However, it is now well established that this enzyme may also be implicated in the regulation of other important biological processes includ- ing bone resorption. Therefore, altered expression levels of Cathepsin L may result in disturbances of bone homeo- stasis and, eventually, in the onset of pathological condi- tions associated with altered bone turnover. These observations support the concept that Cathepsin L may be regarded as an additional target for the development of novel therapeutic options for the treatment of patients with bone diseases. This review provides insight into the most recent advances in understanding the role of Cathepsin L in normal and pathological bone remodeling and discusses the potential clinical and therapeutic applications related to these findings.
| year | journal | country | edition | language |
|---|---|---|---|---|
| 2011-06-01 | Clinical Reviews in Bone and Mineral Metabolism |