6533b7d9fe1ef96bd126c410

RESEARCH PRODUCT

Oxygen in the neonatal period: Oxidative stress, oxygen load and epigenetic changes

Máximo VentoSheila Lorente-pozoJosé Luis García-jiménezAlvaro SolazAnna Parra-llorcaFederico V. PallardóInmaculada Lara-cantón

subject

Period (gene)Physiologychemistry.chemical_elementPure oxygenHyperoxiamedicine.disease_causeOxygenEpigenesis Genetic03 medical and health sciences0302 clinical medicine030225 pediatricsHumansMedicineEpigeneticsChildHyperoxiaOxygen supplementationbusiness.industryInfant NewbornOxygen Inhalation TherapyInfantEpigenomeOxygenOxidative StresschemistryPediatrics Perinatology and Child HealthNeonatologymedicine.symptombusinessInfant PrematureOxidative stressDNA Damage

description

Preterm infants frequently require positive pressure ventilation and oxygen supplementation in the first minutes after birth. It has been shown that the amount of oxygen provided during stabilization, the oxygen load, if excessive may cause hyperoxia, and oxidative damage to DNA. Epidemiologic studies have associated supplementation with pure oxygen in the first minutes after birth with childhood cancer. Recent studies have shown that the amount of oxygen supplemented to preterm infants after birth modifies the epigenome. Of note, the degree of DNA hyper-or hypomethylation correlates with the oxygen load provided upon stabilization. If these epigenetic modifications would persist, oxygen supplied in the first minutes after birth could have long term consequences. Further studies with a robust power calculation and long-term follow up are needed to bear out the long-term consequences of oxygen supplementation during postnatal stabilization of preterm infants.

yearjournalcountryeditionlanguage
2020-04-01Seminars in Fetal and Neonatal Medicine
https://doi.org/10.1016/j.siny.2020.101090