6533b7d9fe1ef96bd126c4ab
RESEARCH PRODUCT
Speciation of chitosan-phosphate and chitosan-nucleotide systems in an NaCl aqueous solution
Daniela PiazzeseConcetta De StefanoAntonio GianguzzaSilvio Sammartanosubject
chemistry.chemical_classificationChemical Health and SafetyAqueous solutionChemistryLigandHealth Toxicology and MutagenesisPhosphorusInorganic chemistrychemistry.chemical_elementToxicologyPhosphatePyrophosphateAdenosineChitosanchemistry.chemical_compoundchitosan nucleotides phosphorus containing ligands chemical speciation polyammonium-phosphate interaction polyammonium-nucleotide interactionmedicineNucleotideSettore CHIM/01 - Chimica Analiticamedicine.drugdescription
AbstractThe speciation of chitosan (310 kDa) with organic (adenosine 5’-monophosphate, AMP, and adenosine 5’-triphosphate, ATP), and inorganic phosphorus containing ligands (phosphate and pyrophosphate) was investigated in NaCl aqueous solutions at I = 0.1mol L−1 and T = 25°C. For all the systems, the investigated results obtained gave evidence for the formation of (chitosan)LHi complex species (L = nucleotides, phosphate and pyrophosphate; i = 1 to 4, but for AMP, i = 1 to 3). The stability data of complex species were used to calculate the sequestering ability of chitosan towards phosphorus compounds considered here, expressed as pL50 i.e., – log(total chitosan concentration) necessary to bind 50% of ligand. The pL50 values, calculated at different pH values, show quite a good sequestering ability of chitosan towards phosphorus compounds, in particular for the ones having higher negative charge, such as pyrophosphate and ATP.
| year | journal | country | edition | language |
|---|---|---|---|---|
| 2010-01-01 |