6533b7d9fe1ef96bd126ca9b

RESEARCH PRODUCT

Scalable and Selective Preparation of 3,3′,5,5′-Tetramethyl-2,2′-biphenol

Thomas QuellRobert FrankeKatrin Marie DyballaNadine HeckenSiegfried R. Waldvogel

subject

010405 organic chemistryLigandChemistryOrganic ChemistryScalabilityOrganic chemistryPhysical and Theoretical Chemistry010402 general chemistry01 natural sciencesCombinatorial chemistry0104 chemical sciencesCatalysisBlock (data storage)

description

Biphenols are indispensable building blocks in ligand systems for organic catalysis. 3,3′5,5′-Tetramethyl-2,2′-biphenol is a particular versatile motif in different catalytic systems. We developed an easy to perform and scalable process to give access to large quantities of this important building block by the use of selenium dioxide, a common and readily available oxidizer.

https://doi.org/10.1021/acs.oprd.6b00356